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- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

A deficiency of Vitamin B12 can lead to advanced anemia where the red cells are fewer in number but are larger than normal (macrocytic)

The Methylcobalamin version of B12 helps reduce homocysteine concentration by converting homocysteine to methionine through a methylation process

What is Vitamin B12, and why is it important

It has a positive effect in preventing many diseases, such as cancer, Parkinsons disease and cardiovascular diseases

therefore, nutritional deficiency of this vitamin is rare in adults in the absence of malabsorption disorders