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In OA research, recent evidence indicates that pharmacological activation of the Nrf2GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Wu et al., 2025b

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It was also found that VIC can inhibit the synthesis of certain types of collagen (types V and VI), allowing for the body to select the type of collagen required for its needs

Do not stop any medications without consulting your prescribing healthcare practitioner

Since the body cannot produce B12 naturally, supplementation is often essential, particularly for individuals with dietary restrictions or those who have trouble absorbing nutrients

Extracellular vesicles: Intercellular mediators in alcohol-induced pathologies