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PloS One (2009) 4(4):e5209

Extended, uninterrupted IGF-1 LR3 use can lead to receptor desensitization and may affect insulin sensitivity over time

Crucially, these findings stem primarily from small, heterogeneous studies using non-standardized extracts/doses, lack robust evidence, and focus on biochemical or symptomatic surrogates rather than clinically relevant hard endpoints, such as endoscopic remission, reduced hospitalizations, or avoidance of surgery