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In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

Studies show liposomal forms increase plasma glutathione levels by up to 28% in just 2 weeks

Studies have shown that in a mouse model of ischemic stroke, the level of GSH in neurons is significantly decreased, the degree of lipid peroxidation is enhanced, and the activity of GPX is decreased 71

Another interesting finding of this study was that adult mice (~4-months-old) displayed the largest changes after acute THC exposure compared to exposed ~1 and ~2-month-old mice, with a general downregulation of the endocannabinoid system

Zahreddine H, Borden KLB