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One way of reducing or even diminishing the capability of PUFAs to become oxidized is to deuterate them, i.e., to replace and exchange their hydrogen atoms with deuterium

Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE

It is therefore not surprising that the olfactory system has one of the highest MT abundances of the mammalian central nervous system, and that expression of the MT-1, -2, and especially -3 isoforms are greatest in the olfactory neurons of the brain and the anatomically adjacent hippocampal region, which has direct nerve fiber projection contacts from the olfactory bulb [94, 101, 103105]