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Here, we characterized the MHC class I-restricted immunopeptidome of IPF to investigate whether fibrotic conditions increased the overall presentation of MHC class I-restricted peptides, whether pathological cell populations in fibrosis presented disease-specific MHC class I peptides and whether therapeutic interventions such as vaccines could be designed based on the discovery of MHC class I ligands associated with pathological cell populations

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In borderline cases, methylmalonic acid or homocysteine levels may be tested

COPD patients suffer from oxidative stress caused by the inhalation of cigarette smoke (CS) or harmful substances which causes an accumulation of pulmonary inflammatory cells (neutrophils, macrophages), leading to large numbers of reactive oxygen species (ROS)

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