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No definitive serious adverse event reports of distant spread of toxin effect associated with BOTOX for blepharospasm at the recommended dose (30 Units and below), severe primary axillary hyperhidrosis at the recommended dose (100 Units), strabismus, or for chronic migraine at the labeled doses have been reported

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203 Another study that followed 25 subjects with one-sided tinnitus and hearing loss for one year found 22 of 25 participants (92%) experienced significant improvement in tinnitus beginning one to two months after implantation

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