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When the body detects these pathogens, the immune system launches a massive defensive response, releasing pro-inflammatory cytokines like IL-6 and TNF- in what is sometimes called a "cytokine storm." While this inflammatory response is necessary to destroy the virus, it comes at a steep metabolic cost

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Neurobiol Aging 32: 1341-1371 Doi 0.1016/j.Neurobiolaging.2009.08.007 Bartzokis G, Cummings JL, Sultzer D, Henderson VW, Nuechterlein KH, Mintz J (2003) White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study

Furthermore, single-cell RNA-sequencing (scRNA-seq) technology (Nojima et al., 2025)