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This highly loaded conjugate demonstrated higher brain uptake than free PTX and significant antitumor activity in vivo in glioblastoma-bearing mice (Rgina et al., 2008)

Dangerous Reactions While die-off symptoms are generally manageable, certain signs indicate you should stop treatment and consult a practitioner: Persistent fever above 101F Severe abdominal pain or vomiting Neurological symptoms worsening (e.g., vertigo, severe headaches) Bloody or black stools Symptoms continuing beyond 7 days These may signal an adverse reaction or unrelated health issue that needs immediate attention

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It usually occurs 2448 h after the start of ECMO and increases the risk for death in critically ill patients (93)

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