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Chronic inflammation Inflammation is a fundamental mechanism that maintains homeostasis in response to tissue damage (Racanelli et al., 2018

Clin Infect Dis 51(12):14291434 de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LAB, van der Meer JWM, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL (2014) IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

NLRP3, the most widely studied inflammasome, is a high molecular mass protein complex composed of NLRP3 protein, Apoptosis-associated Speck-like protein Containing a CARD (ASC), and cysteine aspartate protease 1 (caspase-1)

With topical corticosteroids as the primary treatment, ACD is currently a pathology without a permanent cure

It is produced in a pulsatile fashion and most of it is secreted during periods of deep sleep

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