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Here we mention the three main fragmentation techniques used in the ICR cell, and discuss the advantages and disadvantages of implementing them

doi: 10.1016/j.arcmed.2014.11.015 19 BrochardV.CombadireB.PrigentA.LaouarY.PerrinA.Beray-BerthatV.et al

This process covalently links the 3 splice acceptor site to the 5 splice donor site via a phosphodiester bond, resulting in stable circular RNA structures

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targeted interventions for combined stress are insufficient