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In such case, the photoreaction rate is directly proportional to the concentration of the substance

The reason he calls this a hypothesis, is that even though many studies (some you will see below) have demonstrated this effect, there have not been enough large-scale randomized trials to definitively prove this out

Figure 1: The effects of MA on activity of liver GPx and GR enzymes, values are Means SEM

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The total phenolic content (TPC) results were expressed as milligrams of gallic acid equivalents per gram of dry extract (mg GAE/g DE)

Thus, ample evidence suggests that activation of the 12-LOX and p38 MAPK signalling pathways can stimulate downstream immediate early genes and key signalling kinase molecules that mediate cytokine and growth factor activity and induce DN (Ma et al., 2005)