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Enhanced markers of oxidative stress, altered antioxidants and NADPHoxidase activation in brains from Fragile X mental retardation 1deficient mice, a pathological model for Fragile X syndrome

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(2015, 2017) observed improvements in UPDRS scores with intranasal (in)GSH (4.6 (4.7), P = 0.0025), though the effects were not statistically superior to placebo

JamilianMShojaeiASamimiMEbrahimiFAAghadavodEKaramaliMet al

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GS uses glutamate and ammonia (NH3) as sources to catalyze the biosynthesis of glutamine