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DOI: 10.4161/oxim.3.1.10476 39

Class I and IIa HDACs mediate HIF-1 stability through PHD2-dependent mechanism, while HDAC6, a Class IIb member, promotes HIF-1 transcriptional activity in nucleus pulposus cells of the intervertebral disc

Also, its not advisable to consume large amounts of fish in order to boost dietary fish oil intake due to possible contamination with mercury and other industrial and environmental chemicals