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Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

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Their main finding showed that oral intake of up to 8000 mg/day curcumin for 3 months is well tolerated by patients [407]

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utilized a multi-omics approach to demonstrate that fecal microbiota transplantation (FMT) induces substantial alterations in plasma metabolites and hepatic DNA methylation profiles among patients with NAFLD [28]