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Moreover, it is well known that estrogen reinforces pleiotropic neuroprotective effects on the CNS by playing multiple roles in regulating the etiopathology of MS, including alleviating demyelination, elevating the concentration of anti-inflammatory cytokines, and enhancing energy production (108)

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Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine

The use of pharmacodynamic endpoints for assessing the systemic exposure of topical corticosteroids may be necessary due to the fact that circulating levels are often below the level of detection

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10.1074/jbc.TM117.000258 J