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USA 116 , 1349013497 (2019)

3,47,64 However, Fer-1 has not been pursued in drug development, given its metabolic instability and poor pharmacokinetics

Therefore, as mitochondrial ATP production falls with increasing severity of mitochondrial defects, there is a progressive increase in the number and severity of clinical symptoms

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These were cloned into the pET28a(+) expression vector (Novagen) using the NdeI and BamHI restriction sites and sequence verified