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Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

The pro-inflammatory cytokines are excessively secreted from WAT in either genetic-based or diet-induced obese mice, which in turn interrupt insulin action in adipocytes, contributing to the onset and development of insulin resistance [60]

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Djakovic Z, et al

PMID: 12234984 [29] Kumar P, Liu C, Suliburk JW, et al

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