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Electron-withdrawing groups at positions C2, C3, C7, and C8, reduce activity, while electron-donating groups enhance it (Farmer et al., 2022)

pp 11971199 Boehmerle W, Splittgerber U, Lazarus MB, Mckenzie KM, Johnston DG, Austin DJ, Ehrlich BE (2006) Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism

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