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Global sensitivity analysis is then applied to examine the model behavior and identify the pathways with the greatest impact in control compared to RP conditions

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2 General mechanism of action of antidepressants Currently, antidepressants are primarily classified based on their pharmacological mechanisms, which aim to enhance monoaminergic neurotransmission, especially within the noradrenergic and serotonergic systems ( Monoamine oxidase inhibitors (MAOIs) exert their antidepressant effects by inhibiting the enzyme monoamine oxidase (MAO), responsible for the degradation of monoaminergic neurotransmitterssuch as serotonin, norepinephrine, and dopaminewithin presynaptic neural and mitochondrial compartments (Tan et al., 2022)

cellular transformation), involving DNA damage, are however most affected by ROS generated inflammation

The study demonstrated that dietary supplementation with T3 resulted in enhanced T cell proliferation [146]