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Among other events, FXII is activated to FXIIa to initiate the cascade of proteases

2016 Jul;139(Pt 7):e39

The combination of cetuximab and -elemene not only promotes ferroptosis in CRC cells, but also promotes the expression of E-cadherin (epithelial marker) while reducing the expression of mesenchymal markers such as snail, vimentin, N-cadherin, slug, and MMP-9