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Food Sci Nutr 2021, 9 (5), 27332742

When the gut lining is inflamed and damaged, large proteins enter the bloodstream

Results Increased severity of liver injury and mortality of mice with hepsin deficiency during the early period after acetaminophen exposure To investigate the potential physiological role of endogenous hepsin in the early response to APAP-induced liver injury, we analyzed hepsin expression in wild-type mouse liver lysates following APAP treatment using western blotting (Fig