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Redox Biol 2013, 1:508513

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These variations may result from changes in altitude, diseases that impair blood oxygenation, or defects in glycolytic enzymes, and they affect hemoglobin binding affinity for oxygen

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Similar to lenvatinib and sorafenib, TM inhibits MEK1/2 kinase activity and PTC cell growth, and it enhances the antitumor activity of both sorafenib and vemurafenib [110]

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The Kelch/DGR domain contains six Kelch repeatitions that interact with the ETGE and/or DLG motifs of Neh2 domain of Nrf2 [54]

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GPX4 activity is dependent on Glutathione (GSH) which is synthesized using cystine imported via the cystine-glutamate antiporter, System Xc

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