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It can be rough on the digestive system, for example, capable of causing nausea, bloating, diarrhea, or constipation, and there havent been many studies on its long-term safety.47 So, a berberine supplement thats been through extensive third-party testing will be safer than most, as would one that was manufactured in an FDA-registered facility compliant with Good Manufacturing Practices (GMP)

Several chemical processes can disrupt that structure over time

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When to See a Doctor "If your urine is consistently dark yellow or orange, and adjusting your fluid intake and supplements doesn't work, you should see a doctor, Wallace says