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This approach allows repositioned drugs to enter phases II and III clinical trials more rapidly, with significantly reduced development costs, as pharmacokinetic, pharmacodynamic, and toxicity profiles are already established from earlier preclinical and phase I studies

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The parental K562 cells are represented in black, while the edited K562 cells are depicted in pink

vitamin C and E) is typically not recommended in athletes (except in subjects with very low basal levels of antioxidants) (Reference Margaritelis, Paschalis and Theodorou46) , given they may significantly alter redox state and impair exercise adaptations (Reference Pastor and Tur41)

coli exposed to these compounds differed