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This aberrant activation of PARPs represses the SIRT1 activity and mitochondrial dysfunction, which can be rescued by both PARP inhibitor and NAD + precursors

JMJD3, a gene like UTX, is another demethylase that plays a role in epigenetic reprogramming

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Grice I.D., Mariottini G.L

It is used to treat liver inflammation in patients suffering from the issue

Ethics declarations All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments