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D.KhanzodeS

Acta Endocrinol (Buchar) (2019) 15:2214

Germ-free mouse models Mice lacking all microorganisms and housed in a sterile environment

Villardita C, Smirni P, Vecchio I

In addition, the interaction between tumor metabolism and the acidic microenvironment is bidirectional, as lower pH inhibits enzymes involved in glycolysis (such as phosphofructokinase-1) and may inhibit tumor cell proliferation and survival (112)