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The first TOPBP1 AAD binds to the open protomer, where the engagement of t13 causes the FAT domain to rotate by ~27

In order to make sure that only data of sufficient quality meeting the QC criteria were kept for further analysis, all indicated arrays were removed and QC was performed again revealing overall sufficient quality of the remaining arrays

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Braun, France) per kg of body weight, while for the ITT, mice were injected intraperitoneally with 0.5 U insulin (Actrapid 100UI/ml inj, Novonordisk, Copenhagen, Denmark) per kg of body weight

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doi: 10.1016/S0304-3835(01)00383-4 120 SicinschiL