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A hot spot mutation of cytosine to thymine at nucleotide 454 (C454T) was found in 39% of samples that had a VHL mutation and was not found in renal cell cancers from nonexposed patients or in lymphocyte DNA from either exposed or nonexposed cases or controls

Abbreviations A20: Tumor necrosis factor, alpha-induced protein 3 AIM: Absent in melanoma ACSL: Acyl-CoA synthetase long-chain family member ALA: -lipoic acid ALT: Alanine transaminase AKI: Acute kidney injury AKT: Protein kinase B ARE: Antioxidant response element ASC: Apoptosis associated speck-like protein containing a CARD AST: Aspartate transaminase ATG(s): Autophagy related proteins BAK: B-cell lymphoma 2-antagonist killer 1 BAX: B-cell lymphoma 2-like protein 4 BCSFB: Blood-cerebrospinal fluid barrier CAPN: Calpain cGAS-STING: Cyclic GMP-AMP synthase-stimulator of the interferon gene cIAP: Cell inhibitor of apoptosis protein Cis-Pt: Cisplatin CoP(s): Cobalt-chromium-molybdenum implant wear particle(s) CP: Choroid plexus CTR: Cu transporter DAMP(s): Damage associated molecular pattern(s) DNA: Deoxy-ribonucleic acid DMT: Divalent metal transporter ER: Endoplasmic reticulum ERK: Extracellular signal-regulated kinase FGF: Fibroblast growth factor FSP: Ferroptosis suppressor protein FTL: Ferritin light chain FTH: Ferritin heavy chain GPX: Glutathione peroxidase GSDM(s): Gasdermin(s) GSH: Glutathione HMGB: High-mobility group box HO: Heme oxygenase HMOX1: Heme oxygenase 1 HRI: Hypoxia-reoxygenation injury HRG: Heme responsive gene HSPB1: Phosphorylated Heat shock protein 1 IL: Interleukine JNK: C-Jun N-terminal kinase LDH: Lactate dehydrogenase LOX: Lipoxygenase LPS-ATP: Lipopolysaccharide-adenosine triphosphate Lob-Pt: Lobaplatin KEAP: Kelch-like ECH-associated protein MAPK: Mitogen-activated protein kinase mARC: Mitochondrial amidoxime-reducing component MDA: Malondialadehyde MEG3: Long non-coding RNA maternally expressed gene 3 miR: MicroRNA mRNA: Messenger ribonucleic acid MT: Metallothionein NCOA: Nuclear receptor coactivator NEK: NIMA-related kinase NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NFR: Nuclear factor erythroid 2related factor NLR: Nod like receptor NLRC: NLR family CARD domain containing protein NLRP: NLR family pyrin domain containing PAMP(s): Pathogen associated molecular pattern(s) PI3K: Phosphoinositide 3-kinase PUFA(s): Polyunsaturated fatty acid(s) PTEN: Phosphatase and tensin homolog Pt-B: Platin B RNA: Ribonucleic acid ROS: Reactive oxygen species Sec: Selenocysteine SelM: Selenoprotein M SOD: Superoxide dismutase S

The roles of NRF2 in modulating cellular iron homeostasis