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5.4 Effect of PCs on diabetic complications 5.4.1 PCs and diabetic nephropathy Diabetic nephropathy (DN) is a primary microvascular complication of diabetes mellitus, characterized by proteinuria, glomerular enlargement, reduced tubular filtration, renal fibrosis, and renal dysfunction, ultimately leading to end-stage renal disease (Samsu, 2021)

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