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Several factors can contribute to the onset of toe cramps, including overexertion during physical activities, prolonged periods of sitting or standing, and even wearing ill-fitting shoes

PMID 26290473

The amount of pH adjusting agent (eg, Tris base) can be 0 mg to 300 mg

In a study conducted in the Sentinel System, increased risk was predominantly for squamous cell carcinoma (SCC) and in white patients taking large cumulative doses

Most importantly, exosomes have been shown to transport iron out of the cell to regulate ferroptosis ( Publishers Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A single overdose is typically not dangerous but may cause increased nausea, vomiting, or other GI side effects