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Description

We then performed untargeted metabolomics and found 1154 nonredundant metabolites in the BM microenvironment (Fig

We can therefore consider glutathione to be a safe storage for cysteine

After that, plasma concentrations of NAC declined rapidly in both groups

However, due to the extensive cross-talk of KRAS-mediated signalling pathways, it is difficult to achieve effective inhibition of signalling pathways only by inhibiting a single key molecule, and joint inhibition of multiple key molecules is often required