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Studies on the role of intestinal bacteria in metabolism of synthetic and natural steroid hormones

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More specifically, a decrease in various cytokines such as interferon-gamma, IL-6, and IL-12p40 secretion, and an increase in IL-10 secretion was observed, along with low cell-activation status of antigen-presenting cells (APC) and an inhibition of IL-6 and IL-8 production by TLR2 and TLR4-stimulated monocytes in a dose-dependent manner