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Although the mechanism linking congeners with headaches has been elusive, a recent in vitro study that focused on the congener quercetin offers some insight

Every section assumes that baseline

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Formation of glutamate from glucose requires glycogenolysis, both in the intact chicken brain (Gibbs et al., 1) is not high enough that pyruvate derived from glycogen could be used by the astrocytes as the sole source of pyruvate for carboxylation