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4.4 Ferroptosis Oxidative stress-induced ferroptosis is a distinct form of cell death that is contingent upon iron metabolism and characterized by the accumulation of lipid peroxidation to cytotoxic levels

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The major contribution of this study is the strengthening of evidence to support the control of patients with pyroglutamic acidosis, in addition to proposing PyroGlu as a way to measure oxidative stress

At the molecular level, lower levels of the sealing claudins-3,5, and7 and more pore-forming claudin-2 were reported (82)