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In pyroptosis, ROS act as a key upstream signal for activating the inflammasome, initiating the cleavage of gasdermin D (GSDMD) by caspase-1, leading to cell lysis and a massive inflammatory response [76, 77]

By producing O 2 radicals through the NADPH oxidases, the activated LOXs enhance the phagocytic responses to induce inflammation

A reliance on animal experiments may be misleading, given the substantial changes, not only in UA metabolism but also in its transport, associated with primate evolution 62

It reduces hepatic inflammation and oxidative stress by modulating the SIRT1/Nrf2/NF-B axis, thereby restoring liver function

Development 32 ChaparroR

Androgenic alopecia: cross-talk between cell signal transduction pathways