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XRN2, a 5-3 exoribonuclease, has been shown to participate in mRNA decay [16]

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in fact, recent evidence has shown that boosting astrocytic Nrf2 can have protective effects both in ALS mouse models and in vitro cultures

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Mol Cell Proteomics 19(7):1104-19 2020 PMC7338085 Martin-Perez M, Grillo AS, Ito TK, Valente AS, Han J, Entwisle SW, Huang HZ, Kim D, Yajima M, Kaeberlein M, Villen J