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Description

The main sites of mitochondrial ROS production are complex I (NADH dehydrogenase) and complex III (cytochrome bcI complex)

Another factor is metabolic compensation

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a) T cells Recent studies have highlighted distinct immunological profiles between resistant and sensitive ovarian cancer patients, revealing an immune-inflamed phenotype in tumors after chemotherapy [140,141,142]

Future research should focus on optimizing the bioavailability of AS-IV in oral formulations, elucidating its mechanisms of action within multi-drug combination therapies, and evaluating its clinical efficacy across varied pathological conditions