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To identify cellular proteins that bind m11, we screened cDNA expression libraries from diverse mouse cell lines and tissues with m11Fc, a fusion protein comprising the extracellular domain of m11 (amino acids 1212) fused to a human IgG1 Fc domain, and identified a cDNA encoding mouse CD44, a transmembrane glycoprotein involved in cell adhesion and signalling 12

While some participants reported temporary skin lightening after IV infusions, the study found that 32 per cent experienced adverse reactions, including liver dysfunction and even a case of anaphylaxis

Human trials show modest, inconsistent, and non-durable lightening, with effects fading after treatment stops and much of the research being small or industry-linked

[DOI] [PubMed] [Google Scholar] 73.Dal Negro R., Pozzi E., Cella S.G

[1] This potential selectivity is attributed to the fact that Ipamorelin does not appear, in any way, to affect the secretion of other pituitary hormones

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