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The main treatment for water retention is lifestyle changes, like increasing movement and altering diet

This physiological setback often leads to darker patches of skin, especially on the hands and face

In one notable study, patients who received Vitamin B12 supplements, especially when combined with folic acid and sun exposure, showed re-pigmentation in affected areas

Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic

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