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GLP-1 agonists (semaglutide, tirzepatide) are the most expensive but also produce the most dramatic results, making the cost-per-pound-lost ratio competitive

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raises IGF-1 and carries glucose-tolerance risk Compound Semaglutide (Wegovy) Class GLP-1 receptor agonist FDA Status FDA-approved for chronic weight management Evidence Strength Phase 3 RCTs

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Rizzo G, Lagan A, Rapisarda A, La Ferrera G, Buscema M, Rossetti P, Nigro A, Muscia V, Valenti G, Sapia F, Sarpietro G