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FIGURE 5 3.6 CPT1A protects against SAP in mice by inhibiting the NLRP3/GSDMD-mediated pyroptosis signalling pathway To investigate the protective mechanism of CPT1A in SAP, we assessed the expression changes of proteins involved in NLRP3 inflammasome activation

doi: 10.1016/j.celrep.2018.08.003 52 Chooniedass-KothariS.EmberleyE.HamedaniM

Pentosane polysulphate is a semi-synthetic drug manufactured from beech-wood hemicellulose

NAC 900 mg capsule N-Acetyl-L-Cysteine is a biologically active precursor for the amino acid cysteine which, in turn, is a precursor for glutathione, a tripeptide with antioxidant properties

If seizures recur, the entire process must be repeated, starting again at Step #1 above

Notably, miR-155 and miR-132 are among the dysregulated miRNAs implicated in key pathogenic pathways, including the NF-B signaling pathway, oxidative stress responses, and mitochondrial-mediated apoptosis, all of which contribute to testicular dysfunction and impaired spermatogenesis [14, 15]