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M2 macrophages, as infiltration-rich immunosuppressive cells, are able to activate the PI3K/AKT/mTOR signaling axis by secreting IGF-1 and IGF-2, which promotes thyroid cancer cell invasion and the expression of stemness markers (Oct4, SOX2 and CD133), exacerbating the immunosuppressive effects of cancer (74)

This might be explained by the fact that although EAAT2 and KYNA might be downregulated, there is also a downregulation of system x activity

Spermidine delays aging through multiple pathways, such as the activation of autophagy, the regulation of epigenetic modifications, the improvement of mitochondrial function and the inhibition of inflammation, and has shown potential for improving healthspan in model organisms (yeasts, Drosophila , nematodes, and mice) 429 and humans

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Figure 1a outlines the zoning of the transected nerve as described in the Method