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In ovarian cancer, tumor-released mesothelin, which is linked to a glycosylphosphatidylinositol (GPI) anchor, binds to MR on macrophages, driving their polarization toward the TAM phenotype, which supports tumor growth and suppresses the immune response

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Single-cell transcriptomic and lineage-tracing analyses suggest that resident macrophages mainly contribute to TAM pools within omental metastases and milky spots, whereas monocyte-derived macrophages dominate in ascites [20,73]

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doi: 10.1038/s41598-020-78003-z 191 MortenKJBadderLKnowlesHJ

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Effective lipoxygenase inhibitors, such as CDC and zileuton, are free radical-trapping antioxidants (Yang et al., 2016)

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Having more antioxidants is a way for plants that grow at high levels with lots of UV light to protect themselves

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In addition to commonly used iron chelating therapy, regulating hepcidin levels may also help alleviate iron overload in -thalassemia patients, due to their typically low hepcidin levels

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