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Dense extracellular matrices, abnormal vasculature, and high interstitial fluid pressures significantly restrict nanoparticle distribution, especially in hypoxic tumor cores where immune activation is most needed

Biofactors 27, 13

The resulting paracrine mediators, including extracellular cGAMP and NK cell chemokines, promote macrophage M1 polarization and facilitate NK cell recruitment (Fig

cordifolia extract and part of its compounds have anti-inflammatory activity in different models, but the mechanism of regulating inflammatory was still unclear

Pape et al