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This contrasts with the sizes observed in arthropod hosts, where the genomes can be significantly larger, 1,250,060 bp for w Mel, isolated from Drosophila melanogaster , 1,267,782 bp for w Cle, from Cimex lectularius , 1,587,994 bp for w Pip, from Culex pipiens , and 1,801,626 bp for w Fol, from Folsomia candida [148,281]

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IAC 2022 congress proceedings, 73rd International Astronautical Congress (IAC), Paris, France Acknowledgements The authors would like to thank the Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, for their support in providing infrastructure for the review work

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Also, the combination therapy may be especially valuable to patients with extreme thiopurine sensitivity, resolving hepatotoxicity that some patients experienced during the conventional thiopurine monotherapy (Smith et al., 2012