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10.1111/jcmm.13930 22 FengX.SuredaA.JafariS.MemarianiZ.TewariD.AnnunziataG.et al (2019)

10.1523/JNEUROSCI.23-08-03394.2003 J

Mar/Apr:32-39

This gap provides the central rationale and novelty of the present review

In this study, SFN treatment mitigated the proteinuria and fibrosis seen in the diabetic mice, and also attenuated the kidney levels of profibrotic mediators (TGF- and connective tissue growth factor), inflammatory mediators [plasminogen activator inhibitor -1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1)], and indicators of oxidation (3-nitrotyrosine and 4-hydroxy-2-noneal) [104]