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In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing sperm vitality through plasma membrane peroxidation and loss of membrane integrity, and ultimately compromising overall sperm quality

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Hepatocyte triglyceride accumulation and cholesterol dysregulation also directly drive HSC activation via induction of the Hippo pathway (146, 199)

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Wu CC, Zhang J, Fujimoto J, Song X, Mao X, Sun H, Seth S, Thornton RL, Coyle MD, Little LD, Gumbs C, Behrens C, Chow CWB, Sulman EP, Rao G, Futreal A, Swisher SG , Wistuba II, Heymach JV, Gomez D, Zhang J