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This shows how toxic metals can enter the perivascular space, and then enter astrocytes and oligodendrocytes

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Although specific GSK-3 inhibitors, such as tideglusib, have reached clinical trial and appear to be safe for human use, they have so-far not shown significant therapeutic benefit in mild-moderate AD and further studies are required to optimize dosing and to measure effects at earlier disease stages (Lovestone et al., 2015)

in MPTP-induced PD models, markers of dopaminergic neuron necroptosis (such as phosphorylated MLKL) are significantly upregulated, and RIPK3 inhibition mitigates neuron loss [41]

Clear cell renal cell carcinoma: a comprehensive review of its histopathology, genetics, and differential diagnosis

Acknowledgments We acknowledged Professor Ming Chen from the Zhejiang University for his assistance in the phylogenetic analysis