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(2017) 12:e0178291

Overview The Problem The tests used to determine drug safety have not changed in decades

Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection

Unlike the free form of GW2580, which has a short half-life in vivo, the synthesized NPs demonstrated prolonged retention at the lesion site

USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death[J]